Transport Package: Foil Bag, Drum or Carton (Discreet Package)
Origin: Hubei
Product Description
99% Purity Sorafenib Tosylate CAS:475207-59-1 for Anti-cancer Drugs
1.Product  descroption: Sorafenib tosylate ;anticancer drugs Pharmaceutical raw materials white powder; bodybuilding Sorafenib tosylate Chemical Name: 4 - {4 [3 - (4-chloro-3-trifluoromethyl-phenyl) ureide] phenoxy} pyridine-2-carboxamide p-toluenesulfonate Product Alias: toluenesulfonic sorafenib mesylate Sorafenib Sorafenib p-toluenesulfonic English name: Sorafenib tosylate English Synonyms: Sorafenib (Nexavar) CAS: 475207-59-1 Packing:As requirments
2.COA
Items of analysis
Specification
Results
Description
off-white powder
Conforms
Loss on drying
NMT 1.0%
0.7%
Water content
NMT 0.5%
0.13%
Single impurity
NMT0.1%
0.07%
Total impurity
NMT 0.5%
0.29%
Purity(HPLC)
NLT 99.0%
99.71%
Conclusion
Qualified
 3.More details:
Keywords: Sorafenib tosylate, sorafenib tosylate, mesylate Sorafenib, 475207-59-1 Molecular formula: C21H16ClF3N4O3.C7H8SO3 Molecular Weight: 637.03 Appearance: yellow or white crystalline powder Melting point: 225-235 ºC Loss on drying: Less than 0.5% Heavy metals: Less than 10ppm Total impurities: less than 1.0% Content: 99% Packing: 1kg / aluminum foil bag Uses: toluenesulfonic Sorafenib is a novel multi-target anticancer drugs, can act simultaneously on tumor cells and tumor blood vessels. It has a dual anti-tumor effects: either by blocking the RAF / MEK / ERK-mediated cell signaling  Pathway directly inhibit the proliferation of tumor cells, but also by inhibiting VEGF and platelet-derived Health factor (PDGF) receptors and block the formation of tumor angiogenesis, indirectly inhibit the growth of tumor cells. Â