Vertebrate protein complexes stimulate scar-free tissue repair
Vertebrate protein complexes stimulate scar-free tissue repair August 16, 2018 Source: Science and Technology Daily Scar is a common by-product of human wound repair. It not only affects the appearance of the skin, but also may cause serious clinical dysfunction. Promoting tissue regeneration and repair, and avoiding and reducing scar formation are important topics that people are trying to explore. On the 15th, the Kunming Institute of Zoology, Chinese Academy of Sciences, made significant progress in the study of the formation of protein complexes in the pores to stimulate the repair of scar-free tissue. Tissue repair is a common problem faced by animals during their lifetime. The skin of amphibians bears important physiological functions such as respiration and water-salt balance, and its wound repair must be scar-free so as not to damage the corresponding physiological functions and cause fatal consequences. Unlike traditional membrane proteins such as membrane receptors, ion channels, and transporters, pore-forming proteins are a class of non-classical membrane proteins. At present, the understanding of a large number of pore-forming proteins present in animals and plants is mainly focused on cytotoxicity, and little is known about their physiological and pathological functions and cellular action pathways. Previously, Zhang Yun, a researcher of the Biotoxin and Human Diseases Research Group of the Kunming Institute of Zoology, Chinese Academy of Sciences, discovered the first novel pore-forming protein and trilobal factor complex betagamma-CAT from the amphibians of Yunnan. The national invention patent was obtained, and they also found that the endogenous protein machine has the characteristics of stimulating cell vesicle formation, forming a membrane channel in the endocytosis, lysosome and regulating its function. Recently, the research group Gao Zhenhua and others have further revealed that this complex has the function of inducing tissue repair. Compared with the currently widely used epidermal growth factor EGF, it not only promotes wound healing by accelerating re-epithelialization of skin tissue damage, but also reduces traumatic edema, promotes scar-free healing, and resists the characteristics of drug-resistant infections. . In this study, we discovered an unknown protein-effect molecular complex and a novel cell action pathway for vertebrate tissue wound repair, providing new ideas for further analysis of molecular pathological mechanisms of tissue regeneration and repair and scar formation, and research and development of new disease treatment drugs. It has practical application significance. Relevant research results have been published in the Journal of the American Association of Experimental Biology. (Zhao Hanbin) Insert Pad, the super absorbent core layer adopts a combined absorption structure of polymer absorbent and fluff pulp. It
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