What is the role of Pinellia
1, antiemetic and emetic effect: Pinellia heating processing or adding alum, ginger, a variety of preparations of the preparation, to the water morphine, digitalis, copper sulfate caused by vomiting, have a certain antiemetic effect. The above three emetics have different mechanisms of action, and Pinellia can show antiemetic effects, presumably its antiemetic mechanism is the inhibition of vomiting center. 3, anti-fertility effect: Pinellia protein 1.25mg/ml (in 0.9% NaCl) sc0.2ml of pregnancy inhibition rate for early pregnancy mice was 50%. After the crystalline Pinellia protein is denatured by 6M guanidine hydrochloride, stepwise dialysis (ie, diluting the denaturant with equal volume of the buffer) is used to restore the balance of Pinellia protein in physiological saline. After removing the denaturant, the protein can be renaturalized. Restore its original vitality. The recovery rate of Pinellia protein from different reversal conditions was 69-88% in mice against early pregnancy. Only one reversal condition was 5-8°C, and the rate of inhibition of pregnancy was only 36%. The use of horseradish peroxidase-labeled localization showed specific binding of endometrial cells, ductal epithelial cells, and certain parts of the cytoskeleton of the embryonic exteromal disc and the Pinellia protein. These sites are likely to be part of the anti-progestational role of exogenous protein half protein. Direct injection of Pinellia protein into the uterine cavity of mice also indicates anti-pregnancy effects. If the above binding site is indeed Pinellia protein affecting the implantation of the endometrium and embryos in mice, resulting in anti-pregnancy effects, these sites may also play a role in the identification of the bed, because Pinellia protein can not only terminate the mouse's early pregnancy There is also the effect of stopping the implantation of rabbit blastocysts. Pinellia protein also has a strong anti-rabbit blastocyst implantation, intrauterine injection of 500ug, anti-implantation rate of 100%. The endometrium after the action of Pinellia protein can not implant the normal blastocyst. The blastocysts incubated in the uterus with Pinellia protein were transplanted into a synchronous pseudopregnant uterus, and the implantation rate decreased as the incubation time prolonged. 4. Anti-cancer effects: Pharmacological experiments showed that the dilute alcohol or aqueous leachate of Pinellia pinnatifida had significant inhibitory effects on animal experimental tumors and Hela cells. The fenugreekine base obtained from the water-soluble fraction also has a significant inhibitory effect on mouse liver cancer (HCA). The β-sitosterol and analogues contained therein also have anti-tumor effects. And can obviously promote the gradual shedding of cancer cells and make the cancer shrink or disappear. Clinical pharmacological observations are effective for cervical cancer and have a clear local cleaning effect. 5, antitussive effect: raw Pinellia, ginger Pinellia, ginger soak Pinellia and alum Banxia decoction, 0.6-1g/kgig or iv, cat iodine solution into the chest or electrical stimulation of the laryngeal nerve cough caused by obvious The antitussive effect can be maintained for more than 5 hours. The antitussive effect of 0.6 g/kg was similar to that of codeine 1 mg/kg. 6. Inhibition of trypsin: Pinellia trypsin inhibitor only inhibits the hydrolysis of amides, esters, hemoglobin, and casein by trypsin and does not inhibit chymotrypsin, bradykinin, bacillin, and papain Hydrolysis of the respective substrate. The inhibitory ratios of inhibitors to porcine trypsin hydrolysis of amide, ester, hemoglobin, and casein were 1:0.71, 1:0.88, 1:0.71, and 1:0.71, respectively. From the chemical molecular size range, Pinellia trypsin inhibitor should be a macromolecular inhibitor. 7, the pharmacological effects of processed products: Qing Banxia (according to the Chinese Pharmacopoeia 85 year edition method) decoction 200% concentration of 26.5ml/kg to prevent the administration of cesium chloride induced ventricular arrhythmias in rats have obvious Counteraction (P 100% Water Soluble Vegetable Powder,Powder Vegetable Easy To Digest,Vegetable Spinach Powder,Dried Vegetable Powder Xinghua Dongbao International Trade Co.,Ltd , https://www.xhdongbaofoods.com
2. Inhibiting the secretion of glands: Pinellia preparation ip has a significant inhibitory effect on salivary secretion caused by pilocarpine. It is also reported that saliva secretion increases first and then decreases after decoction po.