No chemotherapy to treat leukemia! New achievements of the Chinese team published in The Lancet
No chemotherapy to treat leukemia! New achievements of the Chinese team published in The Lancet November 06, 2018 Source: Health Times Recently, Professor Huang Xiaojun from Peking University People's Hospital published a research report in the international clinical tumor top magazine "Lancet Oncology" (Lancet-Oncology), introducing "oral arsenic and retinoic acid for the treatment of non-high-risk acute promyelocytic leukemia". "The results of a phase III prospective multicenter randomized controlled trial confirm that "no infusion, no chemotherapy" cures acute promyelocytic leukemia (APL), providing the highest level of evidence-based medical evidence for a new era of non-high-risk APL treatment. Acute promyelocytic leukemia is a malignant hematological disease with a serious onset. The recurrence rate of patients who rely solely on chemotherapy is high, and the overall survival is less than half. The combination of retinoic acid and arsenic in the treatment of acute promyelocytic leukemia is a model for the promotion of original Chinese research results. The cure rate is over 90%, and the non-high risk group accounts for more than 80% of APL patients. Previously, Huang Xiaojun's research team has confirmed for the first time in international trials that oral arsenic and intravenous arsenic have similar efficacy and safety. The results were published in the 2013 International Journal of Oncology, Journal of Clinical Oncology. ). On this basis, Huang Xiaojun's research team achieved good results in non-high-risk acute promyelocytic leukemia patients by communicating with innovative small sample prospective cohorts that did not require traditional chemotherapy drugs, no infusion, and no need to re-hospital after remission. Published in the 2014 New England Journal of Medicine. To further confirm the effectiveness of this innovative treatment, Huang Xiaojun led a multi-center, non-inferior, open, randomized, phase 3 clinical trial conducted at 14 centers across the country. A total of 109 adult non-high-risk APL patients were enrolled in the study, 2:1 randomized to the "oral group" (oral arsenic combined with all-trans retinoic acid) and "venous group" (intravenous arsenic combined with all-trans retinoic acid). And consolidate treatment. The "oral group" had a 2-year event-free survival rate of 97%, and the "intravenous group" was 94%, confirming that the "oral group" was not inferior to the "intravenous group"; the full oral drug regimen could cure non-high-risk groups of acute promyelocytic Patients with cell leukemia do not require conventional chemotherapy. The above results provide a high level of evidence-based medical evidence for the treatment of acute promyelocytic leukemia without “infusion, no chemotherapy, and only two oral medications for acute promyelocytic leukemiaâ€. The various side effects caused by chemotherapy save patients' hospitalization for more than 4 months, greatly improving the quality of life of patients and reducing the burden of medical expenses for patients. At the same time, this research has made China's APL research firmly in the international first phalanx and has become a key force driving the development of this field. In many cases, after a course of treatment with red infrared light, the pain is gone. red light therapy belt,red light belt,led therapy belt,led red light therapy,waist heating red light belt,portable led waist belt Shenzhen Guangyang Zhongkang Technology Co., Ltd. , https://www.szlighttherapymachine.com
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