The original results of central nervous system injury repair have been internationally recognized

The original results of central nervous system injury repair have been internationally recognized

January 31, 2019 Source: Ministry of Science and Technology

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In November 2018, the international neuroscience journal "Experimental Neurology" published the results of the verification test of "Spinal Cord Repair" by the research team of the University of Miami, which proved that the team of Professor Li Xiaoguang in China applied bioactive materials to activate adult endogenous neurogenesis repair. The results of the spinal cord injury study are truly reliable and highly reproducible, marking China's first new model for repairing central nervous system injury with adult "neuronal regeneration." The validation trial was conducted at the initiative and promotion of the 2013 Nobel Prize in Physiology or Medicine and Professor Thomas C. Südhof of Stanford University.

The publication of the results of this verification test has attracted the attention of the neuroscience community. The author of the international neurological field, the highest scientific research award in Germany, and the academician of the German Academy of Sciences, Prof. Frank Bradke, published in "Experimental Neurology", "Reproducibility The key towards clinical implementation of "Corner cord disease treatments?" commented on the results of the verification: "The success of Sino-US cooperation is extraordinary, not only overcomes the obstacles of various objective and subjective factors in spinal cord injury repair cooperation, but also studies other spinal cord injuries. Cooperation has played an exemplary role and provided a broad prospect for the clinical application of NT-3 chitosan bioactive materials. Once the bioactive materials are successfully applied in clinical practice, it will be a milestone in the field of central nerve injury repair. . Not only that, Professor Frank Bradke also highly affirmed the research work of Professor Li Xiaoguang's team on the application of NT-3 chitosan active materials to non-human primate rhesus monkeys (the result "NT3-chitosanenables de novo regeneration and functional recovery in monkeys After spinalcord injury was published in PNAS in May 2018. At the same time, Professor Frank Bradke evaluated the feasibility of the clinical application of Professor Li Xiaoguang's team research results. He believes that although this kind of treatment has the risk of surgery, it has largely avoided the formation of tumors and has very positive clinical application value and significance.

In 2015, Li Xiaoguang's team published two articles in the internationally renowned journal Proceedings of the National Academy of Sciences (PNAS), expounding a new research method for the repair of spinal cord injury, using self-developed bioactive materials for the adult spinal cord. The resting state of the endogenous neural stem cells provides a good microenvironment, guides the proliferation and differentiation of neural stem cells into "new neurons", and successfully repairs spinal cord injury in adult mammalian rats. For the first time, the study found that the local area network composed of newborn neurons can be used as a new model of spinal cord regeneration that reconnects the uplink and downlink sensory and motion information “relay stations”, which has attracted the attention of the international academic community.

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