“A Method for Establishing an Immunodeficient Mouse Model†won the 19th China Patent Excellence Award
Release date: 2017-12-29 Recently, it was learned from the State Intellectual Property Office that the invention patent “A Method for Establishing an Immunodeficient Mouse Model†by the Li Peng Research Group of the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences won the 19th China Patent Excellence Award. The 4th Guangdong Province Patent Excellence Award. The patented technology provides a method for establishing an immunodeficient mouse model by using TALEN technology to construct a fertilized egg that knocks out an immune-related gene, and then transplanting the obtained fertilized egg into a healthy pseudo-pregnant female, and self-crossing through the offspring. The population is expanded to obtain immunodeficient mice with specific gene knockouts. By using the present invention, the method for establishing a mouse model can be shortened from the original two years to two months, and further gene knockout can be performed on the background of different immunodeficient mice to obtain a mouse model with a higher degree of immunodeficiency. . 2018 (2nd) Model Workshop on Animal Models and Major Diseases Research and Application The successful research and development of this patented technology has solved the technical defects of the existing long-term and impure background of establishing immunodeficient mice, and broke through the technical blockade of the United States and Japan against China. The various immunodeficient mouse models constructed by the invention have been widely recognized and applied in the industry, and provide a good tool for basic research in China, and provide an effective evaluation method for clinical transformation of drugs. The NSI strain developed by the award-winning patent is one of the most immunologically defective mouse strains in the world. The research team led by Li Peng has used NSI immunodeficient mice to construct a variety of humanized mouse models, including hematopoietic and hepatic metabolic system humanized mice, as well as lung cancer, liver cancer, leukemia, lymphoma, gastric cancer, esophageal cancer. PDX (patient-derived xenograft) mouse model of nasopharyngeal carcinoma and pancreatic cancer has promoted the research of humanized mice in China. It is the most influential scientific research in China and the most extensive coverage of primary tumors. The model platform provides a solid technical platform for the research of biomedicine in China. Attachment: Information about the winner Patent Name: A Method for Establishing an Immunodeficient Mouse Model Patent No.: CN201310229629.9 Patentee: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences Inventor: Li Peng Liu Zhixin Jiang Zhiwu Wang Suna Yin Ailan Zhong Mei Jia Source: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences Retractable Cable Reel,Portable Water Hose Reel,Retractable Water Hose Reel,Retractable Electrical Cable Reel NINGBO QIKAI ENVIRONMENTAL TECHNOLOGY CO.,LTD , https://www.water-hose-reel.com