CCR5 gene impedes recovery of stroke patients
CCR5 gene impedes recovery of stroke patients February 28, 2019 Source: Science and Technology Daily A few days ago, researchers at the University of California in the United States wrote in the "Cell" magazine that the CCR5 gene hinders the recovery of stroke patients. Previous studies have shown that the CCR5 gene is also a major accomplice to HIV entry into cells. Erythritol For Beverage,Erythritol Keto For Beverage,Organic Erythritol,Erythritol Of Stevia Ningxia Eppen Biotec CO.,LTD , https://www.nxeppen.com
As early as 1996, scientists discovered that the CCR5 protein produced by the CCR5 gene is one of the major receptors for the entry of HIV into human T cells. The role of the anti-AIDS drug Maraviroc is to occupy the binding site of the viral envelope protein gp120 and CCR5 protein, and inhibit the binding of the virus to the receptor.
The research team led by Professor Thomas Carmichael, head of the Department of Neurology at the University of California, found that when mice were injected with Malawi, the control of gait and limbs was unexpectedly enhanced. The researchers speculate that although these mice have no stroke, this finding may still help patients with difficult strokes to return to health as soon as possible.
To demonstrate the role of the CCR5 gene in human stroke recovery, the researchers chose to work with scientists at Tel Aviv University in Israel to track the recovery of nearly 450 patients with mild or moderate stroke. Because the CCR5 gene is often absent from Jews, many of them are Jewish, and some patients lack it.
As expected, patients who lacked the gene recovered better from stroke, both physically and in terms of motor control, even in memory, language function, attention and mental state, compared with patients with normal CCR5 gene. There have been improvements.
Carmichael said that the lack of the CCR5 gene prevents the loss of brain cell connections near the site of the stroke and also stimulates new connections in distant areas of the brain. Conversely, possession of this gene reduces the ability of the patient's brain cells to connect and recombine. Heidi Shabra, director of neuroepitics at New York University's Langon Medical Center, said the findings provide a new approach to the rehabilitation of stroke patients.
In addition to "helping abuse" in AIDS and stroke, previous studies have found that CCR5 gene is also involved in the spread of a variety of tumors, especially pancreatic cancer. Tests have shown that CCR5 protein levels in pancreatic epithelial cells in patients with pancreatic cancer increase, while inhibition of CCR5 protein synthesis can slow cancer metastasis. (Intern reporter Hu Dingkun)