Ginger Pharmacological Research
Pharmacological research 1. The role of the central nervous system ginger ginger on the inhibition of spontaneous movement of mice, can extend the sleep time of cyclizole. The use of dry ginger infusion and Pinellia infusion on the central nervous system is more effective than single use, it has a significant inhibitory effect on the spontaneous movement of mice, and significantly prolonged the sleep time of ginsenoside, suggesting that both have Synergy. Various components of ginger have a central inhibition, to enhance sedation and hypnosis and against the role of central stimulants. Both ginger extracts and water extracts have significant analgesic effects. [4] 2. The role of the cardiovascular system Dry ginger infusion and dry ginger infusion and Pinellia extract can make isolated cardiac autoregulation. Ginger infusion of 0.25g/kg was given intravenously to rats, and a transient increase in pressure was observed first, followed by antihypertensive effect, which enhanced autonomic activity. 3. The role of the digestive system In combination with ginger infusion and Pinellia extract has an inhibitory effect on stress ulcers. Ginger infusion can inhibit gastric juice acidity and gastric secretion, and its role in inhibiting stress ulcers is related to this. However, there are also reports that ginger decoction (4.5g/kg) gavage has no inhibitory effect on stress gastric ulcer, acetic acid-induced gastric ulcer, pylorus-ligated gastric ulcer, and indomethacin-induced gastric ulcer in rats; Artichoke (Ginger decoction pieces made by sand scalding) water decoction (4.5g/kg) gavage has significant inhibitory effect on stress gastric ulcer, acetic acid-induced gastric ulcer, and pylorus-ligated gastric ulcer in rats. However, no effect on indomethacin-induced gastric ulcer. 4. Anti-inflammatory effects of ginger extract and water extracts have obvious anti-inflammatory effects. Ginger infusion and zingerone had no significant effect on carrageenan-induced paw edema in rats. A one-fold increase in zearalenone dose had significant anti-inflammatory effects, and its intensity was weaker than indomethacin 5 mg/kg. The role. 5. The anti-hypoxia effect of ginger ether extract has anti-hypoxia effect, can prolong the survival time of normoxic hypoxia and potassium cyanide poisoning in mice hypoxic; it can also prolong the acute cerebral ischemia and hypoxia induced by decapitated mice. Respiratory maintenance time, but only prolonged survival time for sodium nitrite poisoning mice, no effect on the survival time of mice in the low temperature. 6. Other effects of dried ginger water extract and dried ginger volatile oil can significantly prevent the formation of experimental thrombosis in rats. Ginger decoction (10mg/ml) prolongs clotting time and partially dissolves fibrin. Ginger infusion had a significant inhibitory effect on twitch-induced vomiting induced by copper sulphate, a peripheral antiemetic drug; dry ginger decoction did not inhibit the vomiting caused by apomorphine, a central emetic drug, and digitalis. Dry ginger infusion can inhibit vascular permeability, with Banxia infusion with diuretic effect. Gingerol and zingeone have a significant anti-spiral effect. Drug (poison) science The LD50 of ip of ginger essential oil mice was 1.23±0.11 ml/kg (P=0.95), and the LD50 of ig was 3.45±0.28 ml/kg (P=0.95). Before the death of mice, there have been reduced activity, ataxia, muscle relaxation, lying, neck and abdomen contact cage bottom, and finally died of respiratory paralysis. The LD50 of 1d ig ginger oil (30-60°C) extract of mice was 16.3±2.0ml/kg (p=0.95) for 7 days, and 20 mice were given ig ginger extract (120g crude drug). 7d, see the animal died. The LD50 of dry ginger infusion administered to mouse SC was 33.5 g/kg. ã€Pharmacological effects】 Pharmacological experiments showed that the guinea pig excitatory isolated bowel, excitatory vascular movement center and cardiac respiratory center, excited heart, anti-histamine, antibacterial, inhibit platelet aggregation and so on. Comparison of herbs Contrast with aconite Both of them are hot products, they can both warm and cold, return to the yang to save the adverse, with the use can cure Yin Han Sheng, spleen and yang, abdominal pain, loose stools, diarrhea, as well as death Yang card, quadriplegic Counter-pulses, micro-insects, etc., must be used. The difference is: Fuzi: Poisonous, its warm and cold, strong back to save the sun, for the warm and cold medicine, back to the first drug to save the sun, and good at boosting the fire to help the yang, good governance kidney yang, spleen yang , Xinyang deficiency; and cold and dampness, etc. Ginger: Although it is cold and cold, the power of back to save the sun is not as good as Fuzi, but it can also warm the lungs to drink, in order to rule the cold in the middle of the second coke focus. Compared with galangal Both are the main drugs in the cold and cold, indicating cold spleen and stomach, abdominal cold pain, vomiting and diarrhea embolism, whether it is outside the cold invasion of evidence, or deficiency of yang deficiency can be used in conjunction. Both are often used in clinical practice. The difference is: Dry ginger: used to warm the spleen yang, partial cure spleen cold abdominal pain diarrhea. It can also back to Yang Tongmai, warming the lungs to drink, with the treatment of death Yang card, quadriplegia hiccups, pulse slightly desire, and cold drink cough, cold and cold back, phlegm and more clear and thin embolism. Galangal: Longer than Shiwei Han, good governance stomach cold pain, cold stagnation, stagnation, vomiting embolism. Youth Biotech CO,. Ltd. , https://www.youtherb.com