Human Gastrointestinal Cell Development System Reveals
According to a recent report in the journal Nature Cell Biology, researchers from Peking University have systematically revealed the expression of four digestive tract organs during human embryonic development from the single-cell resolution and whole transcriptome level. Signal regulation mechanisms, as well as precise development pathways and gene expression characteristics between different cell types, have important reference values ​​for the study of gastrointestinal biology and related cancer treatments. The digestive tract mainly consists of the esophagus, stomach, small intestine, and large intestine. It plays an important role in food digestion, waste excretion, and resistance to microbial invasion. It reveals the regulatory networks of gene expression during the development of human embryos and establishes related "cells." "Type mapping" is a major issue in developmental biology. In the latest experiment, the Advanced Genetic Diagnosis Center of Beijing, the Tang Futu Group of Peking University School of Life Sciences, and the Ge Wei Group, teamed up with the Qiao Jie Group of the Third Hospital of Peking University to separate and obtain humans from 6 weeks to 25 weeks. A total of 5277 single cells in the esophagus, stomach, small intestine, large intestine, and adult large intestine of the embryos were subjected to high-precision single-cell transcriptome sequencing, and up to 5T gene expression profile data was obtained. Subsequently, they used a variety of bioinformatics analysis methods to conduct in-depth data mining, a comprehensive and systematic analysis of the developmental processes of these four organs at the level of gene expression regulation. The research team defined 40 different cell types in these four organs through key gene expression characteristics; discovered a series of marker genes specifically expressed in the early, middle and late stages of embryonic development; and systematically studied fetal-to-adult Colonic development and identification of 10 major cell types in the adult large intestine. The researchers said that the new discovery provides comprehensive and comprehensive developmental cell map data for the field of gastrointestinal biological research; it also established a gold standard for gene expression mapping for the in vitro differentiation of pluripotent stem cells into gastrointestinal related cell types. The gene expression level provides an important reference for studying the pathogenesis of cancers associated with these 4 digestive tract organs, especially gastric cancer and colorectal cancer. This research was supported by the Ministry of Science and Technology and the National Natural Science Foundation of China. (Reporter Liu Xia) Our pp foil combined cap is widely used in the hospital and clinical infusion issue.The main working procedures such as injection molding, assembly, inspection, inner packing and outer packing will go under a series of regular management system. During the whole procedures,firstly, we use the injection molding machinery to form a cap with a hole in its head,then we will embed a gasket into the hole and then use a pressing slice to fix the cap and the gasket, at last, we will seal the combined cap with a suitable film on it. We will check the sealing ability to prevent the leakage in application before we ship the cargo. If you are interested in our this type product, your detailed inquiries will be great. Foil Cap,Foil Bottle Caps,Foil Caps For Containers,Aluminum Foil Cap Suzhou CRH New Material Technology Co.,Ltd. , https://www.crh-health.com