US developed a new drug for acute myeloid leukemia
US developed a new drug for acute myeloid leukemia April 13, 2018 Source: Xinhua News Agency A study published in the journal Science and Translational Medicine on the 11th showed that a small protein drug is expected to be used in the treatment of acute myeloid leukemia, and has now entered the clinical trial stage in the United States. Previous studies have shown that if MDMX and MDM2 genes are overexpressed, it will inhibit the activity of the anti-oncogene p53, leading to certain cancers. However, Anti-Cancer drugs researched in the medical field have been limited to MDM2 inhibitors. Researchers at institutions such as the Einstein College of Medicine in the United States have developed a new drug that can simultaneously inhibit MDMX and MDM2, fully activating p53 to exert its anticancer effect. This new drug belongs to the book peptide. The helical structure of the peptide is more stable and prevents the drug from being degraded by the enzyme before it reaches the target. Animal experiments have shown that this new drug can extend the median survival of mice transplanted with human leukemia cells from 50 days to 150 days. About 40% of the mice were even cured by the drug and did not develop for more than a year. The researchers said that the new drug is not only expected to be used for the treatment of acute myeloid leukemia, but also for the treatment of other p53-related cancers. (Reporter Zhou Zhou) NATURAL is one of the most professional Animal Feed Ingredients manufacturers and suppliers.
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