Analysis on the application of high-efficiency coating machine in the pharmaceutical industry
Shandong Chunyu Water-saving Irrigation Equipment Co., Ltd., founded in 2011, is located in Laiwu High-tech Zone, Jinan City. It is a high-tech enterprise focusing on innovative and efficient emitter mold manufacturing and emitter product research and development and production. After nearly ten years of innovation and development, it is the invisible champion enterprise in Shandong Province, and now it is in a leading position in this field in China.
Spring rain people-oriented, build talent highland. At present, the company has 16 high, fine and advanced technical personnel, and cooperates with a number of scientific research institutes, forming a mold design, emitter testing, flow testing and other professional technical personnel team. In recent years, it has obtained 3 invention patents, 33 utility model patents and 3 patent awards. In 2019, it was identified as an intellectual property advantage enterprise in Jinan. It has undertaken 4 provincial science and technology innovation projects and won 2 second prizes of Shandong Science and Technology Progress Award. The company has built Jinan drip emitter mold engineering technology research center, the company has a slow wire cutting, CNC machining center, precision EDM machine, 3D projection measuring instrument, CNC engraving, laser engraving and other advanced processing equipment. Mature technology and rich experience support the excellent quality of Chunyu. Spring Rain pays attention to every link of production, implements 8S management, strictly controls the quality of products at the beginning, the middle and the end, and forms the seamless link of production management. The company has independently researched and developed flat emitter molds with full hot runner, cylindrical emitter molds with full hot runner and other products. With excellent quality, competitive price and good after-sales service, the company is well known at home and abroad, and has been sold well in Egypt, India, Iran, Turkey, Saudi Arabia, the United States and other countries.
With the vision of "building a global professional emitter mold supplier" and the mission of "providing solutions for efficient and innovative production of global water-saving irrigation enterprises", the company takes "scientific and technological innovation to scale new heights; Keep improving, the pursuit of excellence; Honesty and trustworthiness, win-win cooperation "for the values of the enterprise. For the construction of water - saving and resource-saving society to make a positive contribution.
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I. Efficient Coating Machine Process The high-efficiency coating machine is a new type of process developed in the 1940s. It was first produced in the pharmaceutical industry to protect drug tablets. Compared with sugar coating, it has the characteristics of short production cycle, less material consumption and strong moisture resistance. In the coating process, it can be divided into water-soluble coating process and organic solvent coating process depending on the solvent. The purpose of the high-efficiency coating machine is to improve the appearance and to easily identify, mask bad odor, facilitate patient taking, reduce gastrointestinal reactions, control drug release, change drug release curve, protect against moisture, protect from light, and isolate air to increase drug stability. The pharmaceutical ingredients with the compatibility changes are placed in the core and the clothing layer respectively or separately after the coating, so as to avoid other changes. Second, the problems often encountered in the coating and solutions 1, excessive wet and wet is because the spray speed is too fast relative to the drying efficiency, there is no balance between spray and dry. This phenomenon is more likely to occur during the water-soluble coating process because water is more difficult to dry than organic solvents.
Due to excessive humidity, the tablets stick to the wall of the pot or the tablets stick to each other. This will cause the film to be damaged and uneven. To avoid over-wetting, the spray rate must be carefully controlled and the inlet air temperature can be increased. In addition, the addition of talc or magnesium stearate to the coating solution can improve this phenomenon.
2, the surface is rough, not smooth, in most cases, it is caused by spray drying, because the droplets are not spread when the drying is too fast. In addition, the dried polymer particles stick to the surface of the core, which is liable to cause a rough film. This can be improved by increasing the spray rate, lowering the inlet air temperature or shortening the distance between the spray gun and the bed.
3. Orange peel phenomenon This is a situation in which the surface of the film is rough. The droplets are not completely spread on the surface of the core, and dry polymer particles are irregularly distributed on the surface of the core. This is mainly caused by improper drying, which can be avoided by controlling the evaporation rate, increasing the spray speed or shortening the distance between the spray gun and the bed.
4, bridging and filling phenomenon When the outer surface of the tablet is irregular, engraved with the logo letters, the surface of these signs will disappear, filled with coating liquid. This is usually caused by the viscosity of the coating liquid being too large, increasing the amount of solvent or the amount of plasticizer, and this bridging or filling phenomenon will disappear.
5. Differences in film color In many formulations, there are pigments or dyes that are suspended in the polymer coating solution. If the agitation is too slow, it will cause precipitation, resulting in a difference in color between the batch and the batch. If the temperature is too high, the pigment will be easily diffused and the color of the film will be light. This phenomenon can be improved by reducing the amount of plasticizer and stirring the coating liquid.
6. Film rupture This is one of the problems that often occurs in coatings. The polymer film ruptures and cracks occur. This phenomenon may occur after the coating has been carried out for several hours when problems occur. This is due to the prescription. Adding a larger molecular weight polymer to the coating solution or increasing the amount of plasticizer will prevent this from happening.
In short, a successful coating depends on three main factors: the coating prescription: it must be determined according to the purpose of the coating, and it must be carefully selected, or the finished coating material can be used, and it can be prepared at the time of use; Surface finish, hardness and friability must meet the requirements; Equipment: The main process parameters must be well controlled throughout the coating process.
The high-efficiency coater is a new type of process that is being widely used for the coating of pharmaceuticals. The technology is easy to develop and produce, and its application range is extremely wide. In recent years, we have accumulated rich experience in the formulation and production of high-efficiency coating machines. Although there are still some technical difficulties in the coating of traditional Chinese medicine pharmaceutical preparations, the application of this technology will be further expanded with the deepening of research on this technology.