Precision Medical Soft Landing Series (1) Large sample size SNP identification artifact MassARRAY technical characteristics, experimental flow, principle introduction
Precision Medical Soft Landing Series (1) Large sample size SNP identification artifact Accurate medical winds have made a lot of money, and the crowds are busy with the project. The high-precision medical slogan is on the ground, and it falls on its own clinical samples. How do you carry out the project on the ground? How to put the limited cost on the most cost-effective research technology? This is the dream of every experimental dog forever. Genotyping is a hot field of precision medicine, and it is also the hardest hit area for burning money over the years. So the question is, how can we make precision medical treatment achieve a soft landing in the field of genetic testing? Imagine, next door, Lao Wang wants to make a big project, how much does it cost to detect 200 important SNPs in 500 clinical tumor samples? Need a budget of at least 5 million in the usual way? And slow! Don't waste money anymore, now there are artifacts to help, please subtract a zero from the budget! Where is the artifact? - MassARRAY! What about MassARRAY? It is one of the most advanced genetic mutation analysis technologies and is the only device that directly detects SNPs by mass spectrometry. Combining simple and reliable primer extension reactions with advanced MALDI-TOF mass spectrometry, MassARRAY enables rapid and cost-effective genotyping to achieve the highest accuracy and price/performance ratio on the market today. I talked about MassARRAY and inserted a news. On June 27th, the medical laboratory of Jikai Gene was officially launched . We specially invited an old friend of Jikai, and the American Academy of Sciences academician Charles Cantor presided over the ceremony. When it comes to Dr. Charles Cantor, he is a senior academician of the American Academy of Sciences. He is currently the chief scientist of Sequenom Inc., a well-known biotech company in the United States. He is also the director of the Biotechnology Center of Boston University and a professor of biomedical engineering. . He has taught at the University of Columbia Human Genetics and a professor at the University of California at Bakery. He was the first director of the Human Genome Project under the US Department of Energy. He has published more than 450 international academic papers, and has written a three-volume classic textbook "Biophysical Chemistry" and the first textbook of Genomics, Science and Technology of the Human Genome Project. Is Sequenom a familiar company? It is the developer of MassARRAY, one of the inventors of MassARRAY technology. This disruptive technology breaks through the flux bottlenecks and cost bottlenecks of previous SNP typing techniques, making the cost of large sample sizes for multiple SNP sites down by tens of times! Since then, genotyping of massive clinical samples is no longer a nightmare, and there is more artifact in precision medicine! The basic principle of the MassARRAY detection system is matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The main feature is that the product after PCR amplification is added with a SNP sequence-specific extension primer and extends 1 base at the SNP site. The prepared sample analyte is then co-crystallized with the chip matrix, the crystal is placed in a vacuum tube of the mass spectrometer, and then excited by a strong nanosecond (10-9 s) laser, the nucleic acid molecules are desorbed and converted into singly charged ions. These singly charged ions fly in the accelerating electric field vacuum tube to the detector according to their mass-to-charge ratio. The smaller the ion mass, the faster it will arrive. The mass spectrum for MASSARRAY SNP detection ranges from 4000 to 9000 Dalton. In this issue, we introduced MassARRAY, a large sample of genotyping, and the next issue of “Precision Medical Soft Landing Seriesâ€. Let's talk about the King of Guns, which focuses on the genotyping of tumor samples, the Cancer Panel! Food additives refer to chemical synthetic or natural substances added to food for the purpose of improving the quality, color, aroma and taste of food, as well as for the need of preservative and processing technology. Due to the rapid development of the food industry, food additives have become an important part of the modern food industry, and has become an important driving force of technological progress and technological innovation in the food industry. In the use of food additives, in addition to ensuring their due function and role, the most important thing is to ensure the safety and health of food. Food And Beverage Additives,Stevia Erythritol Blend,Sweetener Enhancer Nhdc,D-Psicose Sweetener Powder Xi'an Double H Health Technology Co., Ltd , https://www.xadoubleh.com
