"Starved to death" tumor has a new entry point
Due to the extremely rapid division of cancer cells, the blood vessels at the tumor site grow uncontrolled, providing sufficient oxygen and nutrients to the tumor. The German Cancer Research Center and the University of Heidelberg School of Medicine collaborated to find new entry points for anti-tumor blood vessel growth. Mouse experiments have shown that when a specific signal molecule is turned off, the tumor will form a much smaller number of blood vessels in the late stage, and the tumor grows slower, resulting in less cancer metastasis. The team found that the receptor TIE1, which is made up of endothelial cells, plays a crucial role in the process of angiogenesis. An increase in TIE1 accelerates the growth of blood vessels and the entire tumor, and this effect occurs in the later stages of tumor development. TIE1 also destabilizes the vessel wall, thereby promoting cancer metastasis. According to Silvia La Porter, the first author of the research paper, when genetic means is used to shut down TIE1, tumor growth and metastasis can be inhibited. In mice, 10 mice had lesion metastasis after removal of the primary tumor in 14 mice. In the genetically modified mice, endothelial cells could not form TIE1 receptor, and only 1 of 14 mice were detected. To metastasis. How TIE1 works is still a topic worthy of further study. This molecule is a so-called "orphan receptor", ie a receptor without a binding body. Next, they will study whether they can use the TIE1 gene correction drug to achieve the same effect. The idea of ​​inhibiting tumor angiogenesis is not new. The drug, bevacizumab (Avastin), which was launched in 2005, is based on this principle, which blocks angiogenic factors and inhibits angiogenesis. However, the efficacy of bevacizumab is limited, so scientists around the world are looking for new chemical molecules that can be used in conjunction with them as a combination of treatments to improve efficacy. (Technology Daily) Electric Nail Clipper,Electric Nail Trimmer,Best Electric Nail Trimmer,Electric Fingernail Trimmer Shenzhen Jie Zhong Lian Investment Co., Ltd. , https://www.szmeizon.com