Effect of Gastrodia elata on sleep of mice and natural aging model of experimental animals

October 13, 2022

Effect of Gastrodia elata on sleep in mice
Experimental principle
Gastrodia elata is a Pinggan Xifeng drug. In this experiment, it disappears into the index of falling asleep. The use of pentobarbital sodium with less than hypnotic dose can increase the effect of sodium pentobarbital and make the mice The number of sleeps increases only. This proves that Gastrodia has an inhibitory effect on the central nervous system.
experiment equipment
Balance, syringe (0.25 ml, 1 ml).
drug
Tianma decoction 1g/ml, pentobarbital sodium 4mg/ml, picric acid.
animal
The mouse is 180-220g/only, male or female.
method
It is the standard of falling asleep when the white rat's righting reflex disappears for more than 1 min. The drug-administered group was firstly injected with Tianma Decoction 10g/kg intraperitoneally. After 30 minutes, the pentobarbital sodium was injected into the contralateral side of the pentobarbital sodium 25~30mg/kg; the control group was given only pentobarbital sodium. The number of disappearances in the reverse direction of the animals in the administration group and the control group was compared.
note
(1) Before each experiment, pre-test to find the subthreshold dose of sodium pentobarbital.
(2) Gastrodia elata should be pre-steamed or soaked and then boiled to make the ingredients fully fried.

Experimental animal natural aging model

The life process of mammals is very similar to humans. As the age increases, the tissues and organs of the animal body show degenerative changes and show aging. For example, the immune system is the first barrier to protect itself in the body. With the ageing thymus degeneration, the T cell function is low, the autoantibody is increased, and the stimulating ability of foreign antigen is weakened. Immune changes in old age increase the incidence of certain geriatric diseases. Age-related changes in neurotransmitters, receptors, and certain metabolic enzymes in the brain of the nervous system, manifested as decreased memory, sensation, and decreased attention; in the respiratory system, alveolar cells of the aged animal, elastin/collagen Decreased protein ratio, decreased lung compliance, decreased lung antioxidant function, and increased senile respiratory disease.

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