Professor Hu Wenhui's team eliminates human HIV in the genome
Release date: 2017-04-13 Hu Wenhui, a Chinese scientist at Temple University in the United States, recently reported that they use gene editing technology to effectively eliminate human HIV in multiple organ tissues of humanized mice, and take a step toward human clinical trials. Big step. Previously, Hu Wenhui and others have successfully used gene editing technology to effectively eliminate human cell lines cultured in vitro, T immune cells taken out from AIDS patients, and HIV in transgenic mice. Professor Hu Wenhui, the head of the study (Source: Temple University) Humanized BLT mice refer to immunodeficient mice transplanted with human bone marrow, liver and thymus tissue or cells. The mouse has a human functional immune system, which is consistent with humans by HIV infection and latent methods. It overcomes the drawbacks of conventional mice that cannot replicate certain human diseases and is widely used in AIDS animal experiments. In a recent study published in the American Journal of Molecular Therapy, Hu Wenhui and fellow colleague Kamal Khalili and Pittsburgh University Yang Wenbin first used HIV to infect humanized BLT mice and then used adeno-associated virus. (AAV) As a vector, a CRISPR/Cas9 gene editing tool called "gene scissors" was transported to latent infected mice. Two to four weeks later, they detected a deletion of the HIV genome in multiple mouse organ tissues. Associate Professor Hu Wenhui told Xinhua that the HIV gene is prone to mutation, and virus escape may occur with single-target gene editing. To this end, they proposed a new idea of ​​multi-target gene editing, designed four guide RNA (ribonucleic acid) for HIV transcribed regions and structural regions, which can guide Cas9 enzyme to a predetermined position to achieve multi-target resection, significantly increased HIV removal efficiency. In addition, this virus rejection method does not affect the survival and function of the target cells, that is, "kill only the virus does not kill the cells." Hu Wenhui pointed out that at present, gene editing therapy can not 100% eliminate HIV in animals, but it can significantly reduce the amount of latent virus, so the combination with antiretroviral drugs is a promising AIDS treatment strategy. Source: Technology Media Network Vitamin A in fresh corn also has a certain auxiliary effect on the prevention and treatment of common dry eye, bronchitis, dry skin and nerve paralysis. Fresh corn is rich in lysine (very little in dry corn), which is an essential nutrient for the human body. Studies have found that eating more fresh corn can also inhibit the side effects of anticancer drugs on the human body. The cellulose in fresh corn is more and longer, and its amount is 6 to 8 times that of polished rice and flour. Fiber can make the stool smooth, so eating corn often can prevent constipation and hemorrhoids, and can also reduce the occurrence of gastrointestinal diseases. At the same time, it is also beneficial for preventing rectal cancer, arteriosclerosis, and lowering cholesterol. In addition, fresh corn is a bit hard and needs to be chewed hard when eating, which can exercise the teeth and promote saliva production and strong gums. Waxy Corn,Yellow Waxy Corn,Glutinous Corn Cob,Yellow Glutinous Corn Cob Jilin Province Argricultural Sister-in-law Food Co., Ltd. , https://www.nongsaocorns.com