Scientists reveal key structural proteins of Ebola and other RNA viruses
Scientists reveal key structural proteins of Ebola and other RNA viruses July 07, 2015 Source: Bio Valley Both Ebola and rabies are two human lethal pathogens that belong to the same category of RNA viruses, and they often share a common set of strategies for replication of the viral genome in the host, while other viruses of the same type Including Marburg virus, measles virus, mumps virus and vesicular stomatitis virus; researchers found that vesicular stomatitis virus (VSV) can cause acute illness in livestock, but it does not cause human disease, but as a A model virus is harmful to humans. In a recent research paper published in the international magazine Cell , researchers from Harvard Medical School used electron freezing microscopy to reveal the structure of a specific protein of vesicular stomatitis virus (VSV) at the atomic level for the first time. A special protein called polymerase protein L is very important for the replication of RNA viruses. Researcher Professor Sean Whelan said that now we clearly understand how RNA synthesis plays an important role in RNA viruses. If we can develop a virus-specific target to block the replication of one of the RNA viruses, then reveal the polymerase protein. The fine structure may help us develop new therapies. Scientists know how RNA viruses infect host cells. Viruses can initiate the process of infecting host cells by releasing a large protein-RNA complex. The protein that replicates viral RNA is polymerase protein L, which directs the synthesis of RNA. All enzyme activities required, followed by the addition of a cap-like structure to the ends of the RNA to ensure that it is not destroyed in the cell, thus ensuring protein translation. The antiviral portion of the targeted polymerase molecule was developed based on an understanding of the structure of the polymerase. This method of developing antiviral drugs can help successfully fight HIV and hepatitis C virus infection; but for the negative chain of non-unexpressed segments For RNA viruses, revealing the structure of the polymerase protein L may be more challenging. The polymerase protein L is a large structural protein, whereas large structural proteins are often difficult to produce and purify, and the protein L is also very variable, carrying many functional fragments that are very difficult to separate. In this study, the researchers collected data from multiple virus samples and collected the three-dimensional imaging model of the polymerase protein L of the virus and image alignment studies; the researchers then constructed an atomic model of the VSV virus L protein polypeptide chain. Modeling the structure of this VSV viral polymerase protein L can help to understand the structure and function of the L protein in other similar viruses. Finally, the researchers pointed out that the E protein of Ebola virus and rabies virus seem to be very similar, and there are only slight differences in the exact characteristics of the reactive amino acids, but we know that the functions and results of these proteins are the same; understanding L The fine structure of the protein may help scientists elucidate the importance of RNA synthesis for virus survival. Researchers say they will conduct deeper research later to clarify the structure of key proteins important to the virus, and it will be important for later development of new strategies to combat multiple viral infections.
Organic spinach powder is processed by squeezing fresh spinach juice and spray drying. Fresh spinach has high nutritional value and is rich in antioxidants, especially when fresh, steamed, or quickly boiled.
Our spinach is grown in Shandong province, where the climate and soil conditions are very suitable for the growth of spinach.
Main processing technic: organic fresh spinach, cut, clean air bubble wash, slice, dewatering and drying, steam sterilization (Temperature: > 95°C Time:2′), powder.
1. 100% organic
Organic Spinach powder containing antioxidants including vitamins C, E, and K, beta-carotene, manganese, zinc, lutein, and zeaxanthin (among others), spinach powder is also loaded with flavonoids which act as antioxidants to protect the body from free radicals.
Spinach Powder,Organic Spinach Powder,Dried Spinach Powder,Organic Spinach Juice Powder Organicway (xi'an) Food Ingredients Inc. , https://www.organic-powders.com
Organic spinach powder is with the below advantage
2. non-GMO
3. Gluten-free
4. allergen-free
5. 100% pure vegetable powder without any additive
6. Spinach aroma and flavor