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Gentamicin sulfate is an organic substance. The mechanism of action of gentamicin sulfate is to firmly combine with the specific protein on the bacterial ribosomal subunit, interfere with the ribosomal function, prevent protein synthesis, and cause the error of translating the code on messenger RNA (mRNA) to form a non functional protein. 10% Gentamycin Injection,Gentamicin Injection for Veterinary,Animal Medicine Gentamicin,Gentamycin Sulfate Injection Shandong Unovet Pharmaceutical Co.,Ltd. , https://www.unovetcn.com
Clinically, it is used for sepsis, respiratory tract infection, biliary tract infection, suppurative peritonitis, intracranial infection, urinary tract infection and bacillary dysentery caused by Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, dysentery, Klebsiella, Proteus and other sensitive bacteria.
The product was absorbed rapidly and completely after intramuscular injection, and reached the blood peak concentration (Cmax) in 0.5 ~ 1 hour. The blood elimination half-life (T1 / 2b) is about 2 ~ 3 hours, and can be significantly prolonged in patients with renal dysfunction. Low protein binding rate. It can be distributed in various tissues and body fluids, accumulate in renal cortical cells, and enter the fetus through the placental barrier. It is not easy to enter the brain tissue and cerebrospinal fluid through the blood cerebrospinal fluid barrier. It is not metabolized in the body. It is excreted with urine through glomerular filtration, and 50% ~ 93% of the dosage is excreted within 24 hours after administration.
Hemodialysis and peritoneal dialysis can remove a considerable amount of drugs from the blood and significantly shorten the half-life.
[indications]
1. It is suitable for treating severe infections caused by sensitive Gram-negative bacteria, such as Escherichia coli, Klebsiella, enterobacter, proteus, Serratia, Pseudomonas aeruginosa and methicillin sensitive strains of Staphylococcus, such as sepsis, lower respiratory tract infection, intestinal infection, pelvic infection, abdominal infection, skin and soft tissue infection, complex urinary tract infection, etc. In the treatment of abdominal infection and pelvic infection, it should be combined with anti anaerobic drugs. Gentamicin and other antibiotics are often used in clinic. Combined with penicillin (or ampicillin) can treat enterococcal infection.
2. When it is used for central nervous system infection caused by sensitive bacteria, such as meningitis and ventriculitis, it can be injected intrathecally at the same time as an adjuvant treatment.