Gene sequencing with a mobile phone and a mobile microscope
Recently, researchers published a paper in the journal Nature Communications, which attached a microscope to a mobile phone camera to perform fluorescent products that detect NDA sequencing reactions in cells and tissues. This mobile microscope detects a mutation in the colon cancer-associated KRAS gene that is present in more than 30 percent of colon cancer patients. The significance of mobile sequencing "This study shows that a very simple imaging device, such as a cell phone, can be used to analyze a specific DNA target sequence," said Nilsson of Stockholm University in Sweden. The microscope contains two battery-powered lasers for detecting different fluorophores. There are also white LED lights for brightfield imaging. The lens and external lens of the phone provide 2.6× magnification. The 3D printed microscope platform can manipulate the slides of the sample from three directions. Using this sequencing technology, the researchers amplified and fluorescently labeled the target DNA sequence in colon cancer cells and human tumor samples to detect mutant or wild-type KRAS. After that, they used this mobile phone microscope to image the sequencing results. Gene mutation analysis and DNA sequencing are incredible scientific advances in humans in recent years and have been introduced into clinical medicine. Professor Oacan of the University of California said: "But they are limited to the laboratory and obviously cannot be used in resource-poor or limited environments." Ozcan believes that mobile microscopes can be used in more large and medium-sized hospitals or laboratories. To analyze a specific target sequence. University of Chicago's Tay did not participate in the study, but he believes it is an attempt to popularize high-end molecular pathology measurements. Tay added: "DNA sequencing is the gold standard for detecting cancer types today, but due to resource and cost issues, it is difficult to do it on a daily basis. This mobile microscope can change this situation by reducing costs. The authors designed This technology platform enables targeted sequencing of tumor samples at a point-of-care (POCT) site." Johan Lundin of the Finnish Institute of Molecular Medicine, who also did not participate in the study, said: "The combination of this microscope and sequencing strategy, another advantage of other gene mutation analysis techniques, is the integrity of cells and tissues. You can Create a map showing that the mutation occurred on a particular cell."
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