Hawking may have saved! The United States found the basic pathology of gradual freezing human disease
Release date: 2017-08-21 US researchers published a paper in Neuron on the 16th that they found the basic pathology of amyotrophic lateral sclerosis (ALS): a protein mutation called TIA1 that affects the phase transition behavior of proteins, causing Controls the death of muscle neurons, which in turn leads to ALS. The researchers say the findings may open up new avenues for effective treatment of ALS. ALS, commonly known as "gradual freezing human disease", is a motor neuron disease in which the patient develops symptoms such as muscle weakness, contracture, fasciculation, and atrophy. British scientist Stephen Hawking is an ALS patient. At present, the disease is still incurable. Most patients will die within 3 to 5 years after the disease. In addition, some patients with ALS will develop frontotemporal dementia (FTD), and personality changes and behavioral abnormalities may occur. This time, a research team led by St. Jude Children's Research Hospital and Mayo Clinic researchers explored the disease-causing mutation when analyzing the genome of a family affected by ALS/FTD. Their study found that this mutation causes an abnormality in the TIA1 protein associated with the process of cell phase separation. Further studies have shown that TIA1 mutations occur frequently in patients with ALS; those who carry this mutation also develop ALS. The author of the paper, Paul Taylor of St. Jude Children's Research Hospital, pointed out that this is the first time scientists have found a mutation in this kind of ALS, which changes the phase transition behavior of the protein and thus changes the biological characteristics of the cell. For scientists to develop the first effective treatment of ALS in the future, the direction is indicated: by restoring the balance of cell phase separation in patients, or preventing nerve damage. Taylor also pointed out that the same phase change pathology may also apply to other neurodegenerative diseases including Alzheimer's disease, and they are also seeking to use the same method to study Alzheimer's disease. Source: Technology Daily Fast Shipping Laser Distance Sensor Hi there, Fast Shipping Laser Distance Sensor,Serial Laser Distance Sensors,USB Laser Distance Sensors,RS232 Laser Distance Sensors Chengdu JRT Meter Technology Co., Ltd , https://www.accuracysensor.com
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