The telomere length of DNA can effectively predict cancer risk
The telomere length of DNA can effectively predict cancer risk April 07, 2017 Source: MNT Scientists at the University of Pittsburgh Cancer Institute (UPCI) reported at the AACR annual meeting in Washington, DC that protecting the length of DNA telomeres at the ends of chromosomes can predict cancer risk and become a potential target for future treatment. Studies pioneered by Pete and Singapore scientists have shown that more than expected telomeres are composed of repetitive DNA sequences that are shortened each time a cell divides – associated with an increased risk of cancer. Dr. Arnold Palmer, who is chairman of the UPCI Cancer Prevention Committee, said: "The telomere and cancer clearly have a complex relationship." We hope that by understanding this relationship, we can predict who is most likely to develop certain cancers so that they can take preventive measures, or screen more frequently, and develop treatments to help our DNA maintain or restore its ends. Granule length. Yuan and his colleagues analyzed blood samples and health data from 28,000 Chinese who participated in the Singapore China Health Study since 1993. These data are in line with the participants' health outcomes. As of the end of 2015, a total of 4,060 patients had cancer. Participants were divided into five groups based on their telomere length. Given the effects of age, gender, education, and smoking habits, patients with the longest telomere group were more likely to develop any cancer than those with the shortest telomeres. The organization's chances of developing lung cancer are as high as 66%, the chance of developing breast cancer is 39% higher, the probability of developing prostate cancer is 55% higher, and the probability of developing colorectal cancer is 37% higher. In all cancers, the incidence of pancreas was the highest associated with longer telomeres, and one-fifth of the telomere length of participants was 2.6 times greater than the rate of developing pancreatic cancer. For the three types of cancer, the group with very short and extremely long telomeres is at the most risk--generating a "U-shaped" risk curve. Participants with the shortest telomere length were 63% more likely to have gastric cancer, 72% more likely to have bladder cancer, and 115% more likely to have leukemia. The longest telomere group has a 55% chance of gastric cancer, a bladder cancer rate of 117%, and a leukemia rate of 68%. Professor Yuan, Ph.D., Graduate School of Public Health, Pitt School of Public Health: “We had the idea of ​​this research seven years ago, but it takes three months for the laboratory to complete the quantitative telomere length and only 100 samples, which is not enough to draw any The conclusion of meaning." But ten years later, we were able to run nearly 30,000 samples a year, and we came up with these very powerful insights, showing advances in technology. More complicated is the combination of telomere length and genome-wide analysis. A true understanding of the complex biological phenomena of cancer. Blood Bank Refrigerator,Laboratory Blood Bank Refrigerators,Forced Air Refrigeration System,Refrigerator For Medical Guangdong Widinlsa International Co.Ltd , https://www.gdwidinlsa.com