With $100 million entrepreneurs are subverting the medical imaging industry

Low-cost portable high-quality ultrasound equipment can make the most commonly used imaging technology for doctors more people.

Entrepreneur Jonathan Rothberg is working on a new scanner that, with the size of an Apple phone, can realistically scan the internal structure of the human body using 3D image technology.

Rosenberg said he has raised $100 million in financing to create a new medical imaging device that will likely be as cheap as a stethoscope in the future, and that will make doctors' consultations more efficient. According to the patent literature, this technology relies on a new type of ultrasound chip that may eventually use heat to destroy cancer cells or transmit information to brain cells.

Rosenberg is very good at combining semiconductor technology with biotechnology. He has founded and sold two DNA sequencing companies, 454 and Ion Torrent Systems, to harvest $500 million. This profit is enough for this unconventional rich man to launch the famous Gene Machine yacht in the sea and study some deep hobbies, such as sequencing the genes of mathematical genius.

Currently, the imaging system is developed by the Butterfly Network, a company founded for three years and one of the few highly advantageous companies. Rosenberg believes it will be able to independently finance from 4Combinator, 4Combinator is Rosenberg An incubator created to create and invest in companies that combine medical sensors with artificial intelligence science called deep learning.

Rosenberger did not disclose more about the specific workings of the equipment currently developed by Butterfly, and even the appearance of the equipment was kept strictly confidential. “All the details of the product will be announced at the time of the product launch, which is 18 months later,” he said. But Rosenberg guarantees that the device will be as small as possible, costing a few hundred dollars, can be connected to a cell phone, and can diagnose breast or fetal imaging.

According to Butterfly's patent application report, it aims to develop a simple and versatile new ultrasound scanner that can create real-time 3D images. By placing the instrument on the user's waist, you can observe the internal structure of the abdominal cavity like a glass window.

A conceptual diagram of a small 3D ultrasound imaging device submitted by the Butterfly Network to the Patent Office.

With a large amount of money from Rosenberg and investors including Stanford University and Aeris Capital, Germany will focus on emerging technologies – embedding ultrasonic transmitters along with circuits and processors on semiconductor wafers. . Such a device is referred to as a "capacitor micro-ultrasonic converter", abbreviated as CMUT.

Currently, most ultrasonic detectors use small piezoelectric crystals or ceramics to emit and receive sound waves. But connecting these components requires special tightness, and then connecting the cables to a separate box to process the signal. If there is technology to integrate the ultrasonic components directly onto the chip of the computer, then such devices can be produced in large quantities, and accurate 3D images can be generated more easily by combining with software.

“People have been thinking about such products, but how to implement them and put them into commercial applications has always been a problem.”

During the diagnosis and treatment, the doctor uses the most ultrasound, for example, to check the fetus in the pregnant woman's stomach, to find the soft tissue, such as the tumor in the liver, and to use the sound waves to raise the temperature of the cells to treat prostate cancer.

The idea of ​​ultrasonic microchips dates back to 1994, when Stanford University professor Butrus Khuri-Yakub (a consultant at Rosenberg) produced the first ultrasonic microchip, although Companies including GM and Philips spent ten years trying to commercialize them, but failed in the end due to functional instability and manufacturing difficulties.

“People have been thinking about such products, but how they are implemented and put into commercial applications has always been a problem,” said Richard Przybyla, director of circuit design at Chirp Microsystems, Berkeley, California. The company is developing an ultrasound system that allows computers to recognize human poses. “Maybe a lot of investment and a professional team are the key to realizing people’s vision.”

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