Biosensor breakthrough into a medical industry star
According to Nature's Methodology, the detection and imaging of protein-protein interactions in living cells will become more colorful, thanks to a new technology developed by Canadian scientists. This new approach transforms biochemical processes into more visible color changes, providing cell biologists and neuroscientists with a new tool to help them solve the basic mechanisms of cell biology, the root causes of mental illness, and even development. Problems with novel therapies, etc. Proteins essentially control all biological processes in a cell. Although proteins sometimes act alone, their most common behavior is to interact with other proteins to perform their normal biological functions. The key to detecting protein-protein interactions is to understand normal and abnormal functions in cells. University of Alberta chemist Robert Campbell has developed a new technology called FPX that uses genetically encoded fluorescent proteins to image dynamic biochemical events in living cells and tissues. FPX technology converts changes in protein interactions into instantly visible color changes from green to red (or vice versa). According to Campbell, existing methods for transforming fluorescent proteins into active biosensors for intracellular biochemical processes are not only small but also technically challenging. The new technology provides instant imaging of the interprotein activity process at the cellular level, providing an alternative to existing detection and imaging methods. The FPX technology is based on the green and red dimerization-dependent fluorescent proteins (ddFPs) previously discovered by the Campbell team. In 2012, Ding Yidan, a Ph.D. student at the university, discovered for the first time that the combination of green and red ddFPs in a single cell allowed the protein to turn green or red (either). By introducing modified proteins into living cells and taking advantage of the mutual exclusion of green and red fluorescence, Ding Yidan constructed a variety of biosensors that exhibit significant fluorescence changes in response to biochemical processes of interest. By adding the new dimension of fluorescent protein and designing it as a biosensor that responds to color changes in specific biological events, the Campbell team's new technology provides researchers with the tools to instantly detect significant changes at the cell level, maximizing It reduces the optimization process of various biosensors and provides a common technology for building next-generation biosensors. Campbell said that the new technology has a wide range of applications, which are directly related to practical applications such as basic research in cell biology and drug discovery, and will ultimately help researchers make breakthroughs in life sciences such as neuroscience, diabetes and cancer. . punctuate Scientists use the high sensitivity and specificity of proteases to identify functional substances. This is definitely a great creative practice. This kind of material reaction with very strong selectivity makes biosensing greatly reduce false detection. possibility. This time, Canadian scientists converted the results into instant-visible color imaging, allowing us to see more clearly the "small movements" between proteins in living cells. The means of modern sensing technology are becoming more and more abundant, and the information obtained by people using biomass sensing is more diverse. We hope that in the future, more practical applications will emerge based on this technology, so that technology can really change people's lives. . Handheld Glycohemoglobin HbA1c Analyzer Hba1C Device,Diabetes Test,Glycohemoglobin Test,Glycosylated Hemoglobin Test Wuxi BioHermes Bio & Medical Technology Co., Ltd. , https://www.biohermesglobal.com