How do rare earth materials emit light in emergency detection?
In the Mendeleev periodic table, there is a region consisting of 17 kinds of metal elements, which are rare in nature and often exist in the "earth" particle state of oxides, and are therefore called rare earths. The unique atomic structure of rare earth elements makes it possible to synthesize up-converting luminescent materials (UCP) with unique optical properties. Under the efforts of scientific research workers in China, this material has been widely used in many biological detection fields such as infectious disease prevention and control, clinical emergency testing, food safety screening, biological anti-terrorism, drug screening, etc., which has solved many urgent needs for the emergency industry. . The project "Creation and Multi-domain Application of Real-time Detection System Based on Rare Earth Nano-Up-Transfer Luminescence Technology" recently won the second prize of the 2015 National Technology Invention Award. Turn paper into product troubled scientist The preparation method of the rare earth nano-uplighting luminescent material is similar to the ceramic manufacturing process in China, that is, several rare earth elements are mixed and fired in a high temperature furnace of more than 1000 degrees Celsius. Professor Yang Ruiqi, one of the project leaders and the Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences, told the reporter: "The luminescence phenomenon that is common in nature is 'down-lighting', which is excited by high-energy light, and the emitted light is emitted outward according to the law of diminishing energy. The up-turning luminescent material is just the opposite. Due to the internal energy transition, the low-energy excitation light can be converted into high-energy emission light. This artificial luminescence phenomenon does not exist in nature." Rare earth nano-uplighting luminescent materials can exhibit higher sensitivity and specificity in biological detection. According to Yang Ruiqi, commonly used immunoassay reagents (such as green fluorescent protein) are all down-lighting, and their background fluorescence is very high, which needs to be seen by special equipment. The up-going luminescent material has no background fluorescence and can be seen very clearly without any instrumentation, so the sensitivity of the detection is much higher than that of ordinary down-conversion fluorescence. In fact, researchers have already seen the magic of rare earth nano-evolving luminescent materials, and there are about 10 institutions that have published relevant research papers internationally. However, how to turn a thesis into a product and truly exploit the advantages of this material has always been a problem that has plagued researchers in various countries. Opportunity left to the people Many on-site rapid detection reagents in China were once dependent on imports. "These reagents are expensive and can not achieve a good quantitative detection of a variety of harmful substances at the same time. Accelerating the development of monitoring reagents with independent intellectual property rights in China has always been our consideration." Yang Ruiqi recalled the origin of the project is still difficult to conceal the excitement. That was one day in 2000. The Academy of Military Medical Sciences received a letter from a Shanghai company describing the rare earth nano-eluminating materials and saying that they are using this material to produce light-emitting ropes for guiding roads in fire and underwater rescue. , as well as small gifts for Christmas decoration. They believe that this material must have more valuable uses and are seeking technical support. Seeing this letter, Yang Ruiqi immediately contacted the other party. At that time, the manager of the other party happened to be on a business trip in Beijing. The two men hit it off and signed a cooperation agreement on the spot. "We have agreed that they will do the materials and we will do research and development in the field of biology." So, the Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences and Shanghai Keyan Optoelectronics Technology Co., Ltd. cooperated and successfully established the rare earth nano-evolving luminescent materials in 2002. Immunochromatography technology platform (UPT-LF) as a biological tracer. “From basic research and development to mass production, and finally to the sales system, we are the only team in the world to complete all the links. This is because the team has absorbed multi-disciplinary talents such as nanomaterials, biotechnology, opto-mechatronics, computer software, and fluid dynamics. "We work together to innovate." Yang Ruiyi has counted the growth process of the R&D team: In 2003, the Shanghai Institute of Optics and Fine Mechanics of the Chinese Academy of Sciences joined and successfully developed the UPT biosensor for quantitative analysis of immunochromatographic results. In 2005, the UPT biological emergency detection system was perfected, and 51 patents were applied to establish a patent protection group covering the whole technical aspects of nanomaterials, biological detection and intelligent sensing. In 2007, Beijing Thermal Biotechnology Co., Ltd. joined to promote the industrialization process. In 2011, the research team won the first medical device registration certificate and became the first quantitative real-time inspection technology platform with independent intellectual property rights in China. Reasonable cracking of the mystery of chromatography dynamics In the case of an emergency patient with a heart attack, the results will be very different in 3 minutes and 15 minutes. Yang Ruiqi told reporters that another major breakthrough of the team was to find out the mystery of the dynamics of immunochromatographic detection, greatly shortening the detection time and increasing the speed of reagent development. If you know how the liquid flows on the test strip, you can design the test strip according to the influencing factors and process, and this rule has been little known. In 2012, the research team was assisted by experts from the Institute of Mechanics of the Chinese Academy of Sciences to find the dynamics of immunochromatography. “We know how liquid flow is affected by factors such as particle concentration, protein concentration, additives, etc., and conditions can be selectively adjusted, which increases the speed of reagent development from the past 2 months to 3 months to the current 2 weeks. ~3 weeks, the chromatographic detection time was shortened from 10 minutes to 15 minutes to 3 minutes to 5 minutes. Yang Ruiqi said that the weakness of the existing immunochromatography is the reaction between liquid and solid, and only one target can be detected by a single test. "We want to do multi-target detection and study the reaction of the liquid phase. The stability, speed efficiency and sensitivity of the reagents will be faster. †Breaking international monopolies and ensuring biosecurity China's rare earth ore accounts for 43% of the world's total reserves, accounting for 98% of the world's rare earth market, but has long been limited to low-end raw material exports. The R&D team upgraded the rare earth resources from the low-end ore export industry to the internationally competitive high-tech biomedical technology industry, and opened up a new field of high value-added utilization of rare earth resources. "Our biggest social benefit is to break the monopoly of foreign products. In the past, foreign related instruments sold 160,000 yuan in China and 1,000 test strips. Now our instruments sell tens of thousands of yuan and test papers are tens of yuan." Yang Ruiqi said . The core products of rare earth nano-uplighting technology have been widely used in more than 700 medical institutions and more than 100 disease control systems, and provide bio-safety for major activities. All the research team's achievements were transformed in Beijing. Three production lines of Nissan Rare Earth Nano-on-the-light luminescent materials, 1000 grams of reagents, and 10 biosensors were established, and 15 medical device registration certificates were obtained. China Extract Powder For Use As Dietary Supplement Extract Powder, Extract Powder Manufacturer Shaanxi Kang New Pharmaceutical co., Ltd. , https://www.anabolicsteriod.com