Implantable resonator monitors oxygen content in deep tumors

Recently, a research paper published in the international journal Stroke, researchers from the Norris Cotton Comprehensive Cancer Research Center developed a new technology called electron paramagnetic resonance (EPR) oximetry. Help clinicians directly determine the oxygen content of patients with cancer and stroke at high oxygen levels, and provide some help to standardize disease therapy to effectively improve the prognosis of patients.

Release date: 2015-02-09

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Recently, a research paper published in the international journal Stroke, researchers from the Norris Cotton Comprehensive Cancer Research Center developed a new technology called electron paramagnetic resonance (EPR) oximetry. Help clinicians directly determine the oxygen content of patients with cancer and stroke at high oxygen levels, and provide some help to standardize disease therapy to effectively improve the prognosis of patients.

Oxygen is essential for life, and specific levels of oxygen in cells and tissues are important to maintain the body's normal function, while oxygen plays a vital role in the development and treatment of many diseases, and in the treatment of malignant tumors. Many therapies rely on the level of oxygen. For example, lower oxygen levels in cancer are thought to produce malignant tumors, and they are not the same in different tumor tissues; therefore, direct measurement of oxygen levels is an effective strategy for revealing disease progression. It is critical to improve the oxygen content to promote the effectiveness of the therapy.

However, the determination of oxygen in the deep tissue has been a long-term challenge for scientists. To solve this problem, the researchers developed an implantable resonator consisting of thinner and non-magnetic copper wires. The oxygen content of any tissue deep region was measured; in a series of experiments, the researchers used a disposable oxygen probe implanted into the rabbit's brain to successfully achieve several weeks of monitoring the oxygen concentration in the rabbit brain.

Professor Khan said that unlike other implants, the new implantable resonator is implanted under anesthesia, but the rest of the oxygen measurement operations are non-invasive, so we can treat diseases such as stroke. The patient's real-time oxygen concentration monitoring provides new hope for developing new therapies to improve the oxygen concentration in the cerebral ischemic region of patients and improve patient outcomes.

Finally, the researchers say that this implantable resonator, which uses real-time monitoring of tissue oxygen concentration, is a powerful tool for research in the field of stroke and cancer, where doctors can use it for tumor oxygen levels. The next step is to investigate the dynamic changes of the cerebral oxygenation process in stroke patients through a more in-depth study, so as to provide a basis for research to improve the patient's brain oxygen supply strategy to improve the quality of life of patients.

Source: Bio Valley

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