Nat Med: Breaking the tradition! B cells can prevent premature birth
Release date: 2017-01-04 The proportion of premature babies in the United States and many other countries has risen to 1/6, which is the leading cause of infant deaths and long-term illnesses, with a heavy social and economic burden. A recent study, led by Dr. Kang Chen, an associate professor at Wayne State University School of Medicine, published in Nature Medicine found that mother's B lymphocytes play an important role in resisting inflammation and triggering preterm birth. Scientists and clinicians have previously believed that there are no B cells in the endometrium, so it is considered that B cells are not important for pregnancy. However, Chen's research indicates that late pregnancy B cells not only exist in human and mouse endometrium, but also can induce uterine pressure and infection (the main cause of premature birth), and generate some molecules to inhibit uterine infection and prevent premature birth. An important molecule is called PIBF1. "This study not only reveals the long-neglected role of B cells in maintaining fetal health, but also provides a means to prevent or treat preterm birth using B-cell-derived molecules such as PIBF1," says Chen. Chen's team has validated concepts and efficacy in animal models and patented this potential treatment with the help of Wayne State University's Office of Technology Transformation. “Kang is really amazing. He independently summoned and led an excellent team to complete this original masterpiece, especially considering the many challenges encountered.†Chen’s collaborators gave him a high rating. The first author of the study was Bihui Huang and Azure Faucette, Wayne State University. Original search Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor Source: Bio Valley (micro signal BIOONNEWS) Urologicals,MACA Complex Capsules,Natural MACA Complex Capsules,Health MACA Complex Capsules NOUVASANT GROUP LTD. , https://www.nouvasant.com