Effect of Chinese medicinal materials on the efficacy of ultrafine pulverization
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1. The specific surface area is increased. Compared with the Chinese medicinal materials treated with coarse powder, the ultra-fine treated Chinese medicinal materials have a specific surface area increased by several times, so the dissolution rate in the velocities is increased by several times. And adsorption. The ultrafinely treated Chinese medicinal material has a particle size of about 0.3-10u, and the finer the particles. The greater the surface energy, the greater the adsorption with the human digestive mucosa, increasing the probability of digestion and absorption.
3. The dissolution of the active ingredients in Chinese herbal medicines is achieved by concentration gradient diffusion. In the coarse powder of the medicinal material, each coarse particle is composed of several intact cells, and the medicinal components in the outer layer of the cells diffuse outward according to the concentration gradient, and need to pass through the cell wall of the body to be dissolved in the human digestive juice. Then, the medicinal ingredients in the cells and the cells have not spread out in the same way, and need to pass through several layers of cell walls. If the active ingredient in the drug is vegetable water, the dissolution of the active ingredients mainly depends on the human body's digestive juice. The surfactant component penetrates into the cell structure and combines with the drug component to form a hydrophilic structure, and then spreads out according to the concentration ladder. The speed is very slow, because the retention time of the substance in the human body is limited, so that the absorption utilization is not high. The cell structure is the main factor affecting the dissolution of the drug; if the cell structure is broken, the active ingredient can be directly dissolved and the speed is greatly accelerated.
At present, the theory that the ultrafine pulverization of Chinese medicinal materials can improve the efficacy has been widely recognized; the decoction technology derived from traditional Chinese medicine has also begun to sprout. At present, most of the fried Chinese medicines on the market are water decoction extracts, which are costly and wasteful. Seriously, the medicinal materials with unclear medicinal effects are lacking in value; and the theory of synergy in the effect of traditional Chinese medicine is negated. If ultra-micro technology is used to prepare medicinal herbs, the cost is very low and easy to promote. The whole component is used as a medicine, which makes more sense for precious herbs and medicinal materials with unclear ingredients, which greatly saves resources.
The ultra-micro technology of Chinese herbal medicines will drive the innovation of traditional Chinese medicine preparation technology. The micron-sized particles will produce quantum power. The granules can be granulated without adding (less added) auxiliary materials. The mitigating agent can be used by short fibers of a certain particle size, thus reducing on the one hand. The cost, on the other hand, reduces the volume and reduces the amount taken. After the superfine Drug powder is used, it can be directly used in the manufacture of various traditional Chinese medicines, films, ointments, cosmetics, etc., which can greatly improve the quality of the preparation.
At present, the ultra-micro technology of traditional Chinese medicine has just emerged in China. There are some problems in the methods of particle grading, particle size determination and wall breaking rate measurement. When studying Chinese medicine powder, we often overlook the particularity of Chinese medicinal materials. The extent has affected the further development of this technology.
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