Scientists propose new strategies for cancer
Scientists propose new strategies for cancer December 08, 2016 Source: Bio Valley Previous studies have found that the Hippo pathway kinase LATS1/2 can act as a tumor suppressor, but a recent study published in the internationally renowned journal Cell , scientists from the University of California, San Diego Medical School revealed the kinase through research. LATS1/2 has a special role in inhibiting cancer immunity, and related research or hopes for developing new strategies to improve the efficacy of immunotherapeutic drugs. Researcher Dr. Toshiro Moroishi said that before our study, no one knew that the Hippo pathway could regulate immunogenicity, and the elimination of the kinase LATS1/2 in cancer cells could improve the immunogenicity of tumors, thereby enhancing immunity against tumors. React to destroy cancerous cells. The Hippo signaling pathway regulates organ size by regulating cell growth, apoptosis, and stem cell turnover, but abnormal regulation of the Hippo signaling pathway triggers cancer. In in vitro studies, the researchers found that the deletion of the Hippo signaling pathway kinase LATS1/2 promoted cancer cell proliferation and tumor survival, while the mouse model of lack of immunity found that the Hippo pathway can support the function of tumor suppressors. However, when the researcher Moroishi and colleagues knocked out the LATS1/2 kinase in mouse cancer cells and tested the growth of tumors in the healthy immune system model, they found that the mouse's body's immunogenicity improved, and the mice The body can successfully destroy cancer cells, the researchers said, the immune response of the mouse model is different from the immune response of the human body, so the response of the two is not the same, and further research is needed later. If the results prove to be the same, then only the LATS1/2 kinase inhibitor or the combination of immunological checkpoint inhibitors may be able to stimulate the immune system of patients who have not previously responded to immunotherapy to work again. Most current immunotherapeutic studies have focused on the immune system, but this latest study suggests that tumor cells may also be susceptible to inhibitors. Finally, Dr. Kun-Liang Guan said that inhibition of LATS1/2 kinase may be a potential pathway for the treatment of cancer. LATS is an ideal target because many kinase inhibitors have been successfully developed as anticancer drugs.
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