The latest article on Nature Immunology: The combination of miRNA and expression profiling microarrays reveals a new mechanism for antiviral effects of IFN-a
      Fudan University Shanghai Medical College, Ministry of Education, Yuan Zhenghong research group Laboratory of Medical Molecular Virology, Ministry of Health director, combined with Agilent and Exiqon miRNA microarray chip was found to induce cells to secrete IFN -a extracellular body has passed anti The virus acts on active molecules such as miRNAs and mRNAs , thereby exerting a new mechanism of antiviral activity. The results of July 7, 2013 officially published in the international authoritative journal Nature Immunology, attracted worldwide attention counterparts. INF-a antiviral activity in the cell may be mediated by extracellular body - transfer between cells In vitro The outer cell body antiviral activity of INF-a is transferred from the cells to LNPCs infected hepatocytes In vivo Exosome promotes the antiviral activity of INF-a Molecular analysis of antiviral activity in exosomes Agilent expression profile chip: detection of mRNA Exiqon miRNA chip: detection of miRNA (Kang Cheng provides all chip technology services) Exosome promotes INF-a anti- HBV virus activity Exosome promotes INF-a anti- MHV-A59 and adenovirus activity      Yuan Zhenghong group found, under conditions inducing interferon -a, hepatitis virus (HBV) can be passed by the resistance of liver non-parenchymal cells (LNPCs) is not susceptible to the virus-infected hepatocytes susceptible to infection by extracellular thereof.        By Agilent and Exiqon miRNA microarray chip experiment, LNPCs found extracellularly secreted IFN -a processing enriched in anti-viral mRNA and miRNA. Extracellular body LNPCs sources are liver cells endocytosis, to achieve transfer antiviral molecule between cells; furthermore was found, in vivo experiments in mice, extracellular body involved in interferon -a anti-mouse hepatitis virus A59 and adenovirus anti Virus reaction.       Interferon -a researchers have proposed a new mechanism of antiviral activity: in the induction of interferon -a, extracellular secretion of cellular bodies, extracellular body having carried miRNA and mRNA molecules and other antiviral activity transferred between the cells, so that Play antiviral activity. Significance: By the outer cell body of interferon mediated anti-viral mechanisms -a signal paths found in this study, it may be a common mechanism of inhibition of virus invasion. The study found that not only expands the basic mechanisms of anti-viral interferon -a, more in the future development of the treatment of chronic hepatitis B virus infection and other diseases drug development lay the foundation. Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity. Nature Immunology. 2013. Please request the original text, please contact Kang Cheng sales engineer, or call the toll-free hotline: 400-886-5058 ; 800-820-5058 Ø  Kang Cheng exclusively provides Exiqon miRNA chip technology services , and customers have more than 60 SCI articles, with an average impact factor of 5.5 or more. Ø  Sharp instrument and application for accurate detection of miRNA in serum plasma Ø  Agilent/NimbleGen Whole Genome Expression Profiling Technology Service Ø  Freezing point price reduction: Choose any chip technology service and enjoy a 60% discount on real-time PCR service ! Shanghai Kangcheng Biological Engineering Co., Ltd.
China: In accordance with Article 54 of the Food Hygiene Law of the People's Republic of China, Article 28 of the Hygiene Management Measures for Food Additives, Article 2 of the Hygiene Management Measures for Food Nutrition Enhancers and Article 99 of the Food Safety Law of the People's Republic of China, food additives are defined as: Food additives refer to artificial or natural substances added to food for the purpose of improving quality, color, aroma and taste of food and for the purposes of preservative, fresh-keeping and processing. According to GB 2760-2014 National Food Safety Standard for The Use of Food Additives, food additives are defined as "artificial or natural substances added into food for the purpose of improving food quality, color, aroma and taste, as well as for the needs of anti-corrosion, fresh-keeping and processing technology. Spices for food, base agents in gum-based confectionery and processing AIDS for food industry are also included.
Food Addictives Powder,Tryptamine Powder,Beta-Nicotinamide Mononucleotide Powder,Sucralose Bulk Food Additives Shaanxi YXchuang Biotechnology Co., Ltd , https://www.peptide-nootropic.com
Research Background:
Interferon -a (IFN-a) through intercellular communication, inducing resistance to the virus-infected cells susceptible to never transmitted to the cell, allowing viral replication, amplification efficiency of the antiviral cell; extracellular body (exosome -) intercellular communication intermediary, Active molecules can be delivered at adjacent levels between cells. The exosome-mediated transfer of intercellular functional molecules is likely to be a mechanism of interferon-mediated antiviral responses.
Research ideas: 
Original source:
More information:
Address: 2nd Floor , Building 63, No. 421 , Hongqiao Road , Shanghai
National toll-free hotline: 400-886-5058 ; 800-820-5058
Phone: 021-64451989
Fax: 021-64452021
Website: