Nature: The process of capturing coronavirus-infected cells using an electron microscope
Nature: The process of capturing coronavirus-infected cells using an electron microscope March 04, 2016 Source: Bio Valley Image source: medicalxpress.com March 2, 2016 / Bio Valley BIOON / -- Recently, in a research report published in the journal Nature , researchers from the University of Washington and other places have obtained atoms that promote the entry of coronavirus into the cell's protuberance proteins. The model, which analyzes the model or provides an idea for developing a special vaccine against coronavirus infection. The coronavirus containing the protuberance protein is the chief culprit in causing almost one-third of the world's atypical pneumonia, but the lethal form of the coronavirus SARS-CoV (atypical pneumonia virus) and the MERS-CoV that emerged in 2012 appeared in 2002. The mortality rate (Middle East Respiratory Syndrome Coronavirus) is between 10% and 37%. The outbreak of lethal pneumonia indicates that coronavirus can be transmitted from a variety of animals to the human body. Currently only six coronaviruses can infect humans, but many coronaviruses can infect animals in their natural state, and the lethality caused by coronary disease. Disease outbreaks may overcome the barriers of species, suggesting that other new types of coronaviruses with epidemic potential may exist, but there are currently no effective vaccines or therapies for SARS-CoV or MERS-CoV. In this study, the researchers used single-particle cryo-electron microscopy and a supercomputer to reveal the structure of the mouse coronavirus glycoprotein trimer. The researcher Veesler said that the structure is in a pre-fusion state. It then undergoes major rearrangements to induce fusion of the virus and host cell membranes, which in turn initiates infection. The researchers found a fusion "machine" of coronaviruses in another family of viruses called paramyxoviruses, including respiratory viruses and viruses that cause mumps, the researchers noted, coronavirus and paramyxoviruses. Fusion proteins can have similar mechanisms to promote viral entry into cells, and they share the same common evolutionary origin process. The researchers compared the crystal structures of mouse and human coronavirus partial protuberance proteins. They analyzed the structure of potential targets for future vaccine design or antiviral therapy, and found that the outer edge of the coronavirus neurite trimer contains A fusion peptide (a series of amino acids) that is involved in the process of the virus entering the cell. This property of the fusion peptide may help scientists design new vaccines to neutralize the infection of many viruses. Finally, the researchers said that there may be a way to generate a broad spectrum of neutralizing antibodies to recognize the peptides of the virus, and neutralizing antibodies will also protect the body from infection by blocking the virus's specific mechanism, which may be It is possible to help protect against infections like viruses such as coronavirus, and later researchers will invest more in research in related fields. (Bio Valley Bioon.com) Utility Knife,Abs Utility Knife,Aluminium Utility Knife,Plastic Grip Utility Knife Shangqiu City Huashang Zhiyuan Tools Co., Ltd. , https://www.hszytools.com