Scientists are developing formulations for 3D printed bone materials
To create a good frame to fill the missing bones, use 30% powdered natural bone plus some special artificial plastics, and then use a 3D printer to print the desired shape. This is the conclusion of a paper by Johns Hopkins University researchers published online in the journal ACS Biomaterials Science & Engineering on April 18. Scientists at Johns Hopkins University say that about 200,000 people need to change their head or face bones every year because of birth defects, trauma, or surgery. To date, the best treatment for these patients is to remove a segment of the bone from the patient's humerus that does not bear the weight of the body, then cut it into the desired shape and implant it in the correct position. But Dr. Warren Grayson, an associate professor of biomedical engineering at the school's medical school, believes that this method not only causes leg trauma, but because the tibia is relatively straight, it is difficult to fit the curve of the face particularly well. To solve this problem, the researchers turned to 3D printing technology. It is well known that this technique is very good at making extremely precise structures with plastics – including accurate anatomical structures. However, "cells placed on plastic scaffolds require some guiding factors to be converted into bone cells." Dr. Grayson said: "The ideal stent is another bone, but natural bones often cannot be reshaped very accurately." To this end, Grayson and his team hope to experimentally find a composite to 3D printed bone scaffolds that combine the strength and printability of plastic with the biological "information" that exists in natural bone. Scientists initially chose polycaprolactone (PCL), a degradable polyester that is often used to make polyurethanes that have been approved by the FDA for clinical use. “PCL will melt at 80 to 100 degrees Celsius, which is lower than most plastics, so it is a good mix for biomaterials that are usually damaged at higher temperatures.†Grayson team Graduate student Ethan Nyberg said. Despite the high intensity of the PCL, the research team learned from previous studies that it does not support the formation of new bones well, so scientists mixed it with bone meal. This bone meal is made by pulverizing the porous bone inside the cattle knee bone after peeling off the cells. fresh frozen brama brama Frozen Brama Brama,Fresh Frozen Brama Brama,Fresh Frozen Brama Brama Skinless,Fresh Brama Brama Fish Zhoushan Junwei Aquatic Products Co., Ltd. , https://www.junweiaquatic-intl.com