The last line of defense against human antibiotics
The last line of defense against human antibiotics December 18, 2015 Source: Bio Valley Chinese and foreign researchers have recently discovered a "superbug" gene in livestock and humans that fights potent antibiotics, which means that the "last line of defense" in human antibiotics is at risk of being compromised. Researchers have called for greater control over antibiotic abuse. The research was jointly conducted by Liu Jianhua of South China Agricultural University, Shen Jianzhong of China Agricultural University, and Jim Spencer of the University of Bristol in the United Kingdom. The results were published in the new issue of British Lancet-Infectious Diseases. . The researchers analyzed pork samples collected from pork, chicken, and human patients and found that there is a special gene, MCR-1, which carries strong resistance to polymyxin and can also be used. Transfer quickly to other strains. With the increasing use of antibiotics by humans, the problem of bacterial resistance has become increasingly prominent. At present, the most antibacterial polymyxin is regarded as the “last line of defense†for antibiotics. When traditional antibiotics such as penicillin and tetracycline gradually fail, medical personnel can only choose polymyxin. Researchers believe that MCR-1 will also disable polymyxin. From 2011 to 2014, researchers collected bacterial samples from pigs, farmers' markets and supermarkets sold in Chinese slaughterhouses, and analyzed the pathogens in patients in two hospitals in Guangdong and Zhejiang. The results showed that the MCR-1 gene was highly prevalent in the samples of E. coli collected from animals and raw meat, and the proportion of positive samples increased year by year. In the samples of E. coli and Klebsiella pneumoniae collected in 1322 patients, there were also Sixteen samples contained the MCR-1 gene. The proportion of positive samples in humans is lower than in bacterial samples collected on animals. The researchers speculate that the resistance of MCR-1 to polymyxin may be due to animals, but has begun to spread to humans. Given the current widespread use of polymyxin in agriculture and animal husbandry, several researchers have suggested that all unnecessary use of polymyxin should be limited as much as possible. The study found that the MCR-1 gene is present on the bacterial plasmid, which is a transferable circular DNA that facilitates the transfer and exchange of genetic material between different strains. This means that MCR-1 may continue to spread, eventually bred a "superbug" in collaboration with other drug resistance genes. The researchers believe that although the current discovery of MCR-1 is limited to China, the gene is likely to spread around the world like other drug-resistant genes. They called for the urgent establishment of a global collaboration mechanism for drug-resistant bacteria and close monitoring and research cooperation. One-stop solution, one machine multi-test
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